Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 6/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | PPOX | P50336 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091853 | 0.90 | SERPINE1 (0.52) | SERPINE1HPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL8091902 | 0.88 | SERPINE1 (0.49) | SERPINE1HPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL8083705 | 0.88 | SERPINE1 (0.49) | SERPINE1HPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL8083815 | 0.82 | SERPINE1 (0.61) | SERPINE1SMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL8092253 | 0.79 | USP10 (0.48) | SERPINE1HPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL8091742 | 0.79 | SERPINE1 (0.52) | SERPINE1SMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL8092259 | 0.77 | USP10 (0.44) | SERPINE1SMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL8083681 | 0.77 | MAPT (0.41) | SERPINE1HPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL8083684 | 0.76 | SERPINE1 (0.40) | SERPINE1HPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL8606858 | 0.76 | MEN1 (0.39) | SERPINE1HPGDSMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136805-A | Quinoxaline dione derivatives, their production and their use in medicaments | SCNERING AKTIENGESELLSCHAFT (DE) | 2000-10-24 | — | — | US | disclosed |