Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 10/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091918 | 0.90 | SERPINE1 (0.50) | SERPINE1MAPTSMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL8083815 | 0.90 | SERPINE1 (0.61) | SERPINE1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8091902 | 0.90 | SERPINE1 (0.49) | SERPINE1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8083705 | 0.90 | SERPINE1 (0.49) | SERPINE1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL8091742 | 0.86 | SERPINE1 (0.52) | SERPINE1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8083681 | 0.86 | MAPT (0.41) | SERPINE1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8083684 | 0.85 | SERPINE1 (0.40) | SERPINE1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8090673 | 0.78 | SERPINE1 (0.55) | SERPINE1MAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL8090611 | 0.78 | SERPINE1 (0.55) | SERPINE1MAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL8090680 | 0.77 | SERPINE1 (0.47) | SERPINE1MAPTCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136805-A | Quinoxaline dione derivatives, their production and their use in medicaments | SCNERING AKTIENGESELLSCHAFT (DE) | 2000-10-24 | — | — | US | disclosed |
| EP-0828746-A1 | NOVEL QUINOXALINE DIONE DERIVATIVES, THEIR PRODUCTION AND THEIR USE IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037500-A1 | NOVEL QUINOXALINE DIONE DERIVATIVES, THEIR PRODUCTION AND THEIR USE IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-11-28 | — | — | WO | disclosed |