Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 2/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2096002 | 0.81 | NOS3 (0.46) | NOS3NOS1NOS2TAAR1GBA1 | |
| SCHEMBL8109498 | 0.79 | NOS3 (0.41) | NOS3NOS1NOS2TAAR1GBA1 | |
| SCHEMBL1830037 | 0.79 | NOS3 (0.50) | NOS3NOS1NOS2TAAR1GBA1 | |
| SCHEMBL8096422 | 0.76 | NOS3 (0.39) | NOS3NOS1NOS2TAAR1GBA1 | |
| SCHEMBL8111450 | 0.74 | SLC6A4 (0.41) | NOS3NOS1NOS2TAAR1 | |
| SCHEMBL5654987 | 0.74 | NOS3 (0.54) | NOS3NOS1NOS2TAAR1GBA1 | |
| SCHEMBL52608 | 0.74 | NOS3 (0.54) | NOS3NOS1NOS2TAAR1GBA1 | |
| SCHEMBL8086082 | 0.73 | TACR1 (0.45) | ALDH1A1 | |
| SCHEMBL42737 | 0.73 | NOS3 (0.53) | NOS3NOS1NOS2TAAR1GBA1 | |
| SCHEMBL11669280 | 0.71 | NOS3 (0.51) | NOS3NOS1NOS2TAAR1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080743-A | AS CHEMICAL INTERMEIDATES FOR PREPARING DRUGS | NOVARTIS AG (CH) | 2000-06-27 | — | — | US | disclosed |
| EP-0853617-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | Novartis AG (CH) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997008155-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |