Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 7/20 | 0.39 |
| ▸ | CA1 | P00915 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092502 | 0.95 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8092307 | 0.88 | PIK3CA (0.39) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8099045 | 0.87 | MAPT (0.39) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8100131 | 0.87 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8092406 | 0.87 | PIK3CA (0.41) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8084013 | 0.87 | PIK3CA (0.41) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8105037 | 0.86 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8084155 | 0.86 | MAPT (0.39) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8084171 | 0.85 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8090321 | 0.85 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |