Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.33 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092498 | 0.88 | PIK3CD (0.49) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8100085 | 0.87 | NAMPT (0.38) | PIK3CAPIK3CDCA1CA2KDM4E | |
| SCHEMBL8084155 | 0.86 | MAPT (0.39) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8092502 | 0.86 | PIK3CD (0.45) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8099045 | 0.86 | MAPT (0.39) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8100131 | 0.84 | PIK3CD (0.42) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8091293 | 0.83 | MAPT (0.42) | PIK3CAMTORPIK3CGCA1CA2 | |
| SCHEMBL8084166 | 0.83 | ALDH1A1 (0.45) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8099683 | 0.81 | PIK3CD (0.39) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8089052 | 0.80 | CA2 (0.41) | PIK3CAPIK3CDCA1CA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |