Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091293 | 0.91 | MAPT (0.42) | MAPTKDM4EHTTCNR2PIK3CA | |
| SCHEMBL8097689 | 0.90 | ALDH1A1 (0.40) | PIK3CAPIK3R1ALDH1A1PIK3CDMTOR | |
| SCHEMBL8099045 | 0.89 | MAPT (0.39) | MAPTKDM4EHTTCNR2PIK3CA | |
| SCHEMBL8084166 | 0.87 | ALDH1A1 (0.45) | MAPTKDM4EHTTPIK3CAALDH1A1 | |
| SCHEMBL8092307 | 0.86 | PIK3CA (0.39) | MAPTKDM4EHTTPIK3CAPIK3R1 | |
| SCHEMBL8090246 | 0.86 | PIK3CA (0.42) | MAPTKDM4EHTTCNR2PIK3CA | |
| SCHEMBL8092498 | 0.86 | PIK3CD (0.49) | MAPTKDM4EHTTPIK3CAALDH1A1 | |
| SCHEMBL8084829 | 0.85 | ATR (0.41) | MAPTKDM4EPIK3CAALDH1A1ATR | |
| SCHEMBL8092502 | 0.84 | PIK3CD (0.45) | MAPTKDM4EPIK3CAALDH1A1THRB | |
| SCHEMBL8097463 | 0.84 | PIK3CA (0.39) | MAPTKDM4EHTTCNR2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |