Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL11423003 | 0.92 | ALDH1A1 (0.47) | ALDH1A1TSHRTP53MEN1CYP1A2 | |
| Paraben SCHEMBL9564943 | 0.92 | CA2 (0.59) | ALDH1A1TSHRTP53MEN1CYP1A2 | |
| Benzoic Acid SCHEMBL235923 | 0.92 | TSHR (0.56) | ALDH1A1TSHRTP53MEN1CYP1A2 | |
| Benzoic Acid SCHEMBL505772 | 0.92 | TSHR (0.56) | ALDH1A1TSHRTP53MEN1CYP1A2 | |
| Benzoic Acid SCHEMBL11436200 | 0.92 | TSHR (0.56) | ALDH1A1TSHRTP53MEN1CYP1A2 | |
| Benzoic Acid SCHEMBL5079229 | 0.88 | TSHR (0.56) | ALDH1A1TSHRTP53MEN1CYP1A2 | |
| Terephthalic Acid SCHEMBL11490240 | 0.86 | TSHR (0.63) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL2687529 | 0.86 | TSHR (0.63) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL8506032 | 0.86 | TSHR (0.63) | ALDH1A1TSHRTP53SMN1; SMN2SRD5A2 | |
| Benzoic Acid SCHEMBL2160789 | 0.85 | TSHR (0.48) | ALDH1A1TSHRTP53MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106631779-B | Polyol esters and their use in processing halogenated vinyl polymers | 济南金昌树新材料科技有限公司 | 2020-07-14 | — | — | CN | disclosed |
| EP-1055971-A1 | Toner, developer compositions, process of imaging, polyester and process for preparation of polyester | Xerox Corporation (US) | 2000-11-29 | — | — | EP | disclosed |
| US-4264751-A | BY REACTING A DIOL, A DICARBOXYLIC ACID AND A CHAIN BRANCHING AGENT | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1981-04-28 | — | — | US | disclosed |
| US-4157261-A | PHOTOINITIATOR, CHLORINATED POLYOLEFIN BINDER | FUJI PHOTO FILM CO., LTD. (JP) | 1979-06-05 | — | — | US | disclosed |