Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.72 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MPO | P05164 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065566 | 0.90 | SIGMAR1 (0.88) | SIGMAR1MAOACHRM2GAAMAPT | |
| SCHEMBL11883482 | 0.88 | SIGMAR1 (0.84) | SIGMAR1MAOACHRM2GAAMAPT | |
| Bromide SCHEMBL11691228 | 0.88 | SIGMAR1 (0.84) | SIGMAR1MAOACHRM2GAAMAPT | |
| SCHEMBL3833711 | 0.87 | GAA (0.74) | SIGMAR1MAOAGAAMAPTBCHE | |
| Hydrochloric Acid SCHEMBL3837992 | 0.85 | GAA (0.78) | SIGMAR1MAOAGAAMAPTBCHE | |
| SCHEMBL41690 | 0.84 | MAOA (0.72) | SIGMAR1MAOACHRM2GAAMAPT | |
| SCHEMBL6014422 | 0.84 | SIGMAR1 (1.00) | SIGMAR1MAOACHRM2GAAMAPT | |
| SCHEMBL3441609 | 0.84 | SIGMAR1 (0.75) | SIGMAR1MEN1KMT2A | |
| SCHEMBL9523764 | 0.84 | SIGMAR1 (0.70) | SIGMAR1MAOACHRM2GAAMAPT | |
| SCHEMBL16869725 | 0.82 | MAOA (0.76) | SIGMAR1MAOACHRM2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |