Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL260847 | 0.83 | ALDH1A1 (0.52) | ALDH1A1HIF1ACYP1A2TDP1HSPB1 | |
| SCHEMBL29617011 | 0.83 | ALDH1A1 (0.52) | ALDH1A1HIF1ACYP1A2TDP1HSPB1 | |
| SCHEMBL136817 | 0.78 | CYP1A2 (0.62) | ALDH1A1HIF1ACYP1A2TDP1GPR35 | |
| SCHEMBL8703100 | 0.78 | HSD17B10 (0.46) | ALDH1A1HIF1ACYP1A2SNCATDP1 | |
| SCHEMBL830636 | 0.77 | ALDH1A1 (0.56) | ALDH1A1HIF1ACYP1A2TDP1CYP3A4 | |
| SCHEMBL29471963 | 0.77 | ALDH1A1 (0.56) | ALDH1A1HIF1ACYP1A2TDP1CYP3A4 | |
| SCHEMBL1869106 | 0.75 | ATM (0.46) | ALDH1A1HIF1ACYP1A2SNCATDP1 | |
| SCHEMBL5333075 | 0.75 | CYP1A2 (0.66) | ALDH1A1HIF1ACYP1A2SNCATDP1 | |
| SCHEMBL12982928 | 0.74 | ALDH1A1 (0.49) | ALDH1A1HIF1ACYP1A2TDP1HSPB1 | |
| SCHEMBL30885438 | 0.74 | ALDH1A1 (0.49) | ALDH1A1HIF1ACYP1A2TDP1HSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |