Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 12/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TAS2R10 | Q9NYW0 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL114504 | 0.96 | TDP1 (0.61) | KDM4EALDH1A1TDP1CA2CA4 | |
| Terephthalic Acid SCHEMBL8434830 | 0.95 | ALDH1A1 (0.55) | KDM4EALDH1A1TDP1CA2CA4 | |
| SCHEMBL9134232 | 0.92 | ALDH1A1 (0.52) | KDM4EALDH1A1TDP1CA2CA4 | |
| Aminobenzoic Acid SCHEMBL5875024 | 0.92 | KDM4E (0.52) | KDM4EALDH1A1TDP1CA2CA4 | |
| SCHEMBL9136239 | 0.89 | ALDH1A1 (0.49) | KDM4EALDH1A1TDP1CA2CA4 | |
| Bicarbonate SCHEMBL988121 | 0.88 | ALDH1A1 (0.71) | KDM4EALDH1A1TDP1ALPLPOLB | |
| Bicarbonate SCHEMBL988119 | 0.88 | ALDH1A1 (0.71) | KDM4EALDH1A1TDP1ALPLPOLB | |
| Isophthalic Acid SCHEMBL8434395 | 0.88 | TDP1 (0.55) | KDM4EALDH1A1TDP1CA2CA4 | |
| SCHEMBL9132276 | 0.88 | TSHR (0.51) | KDM4EALDH1A1TDP1ALPLPOLB | |
| SCHEMBL9134552 | 0.87 | ALDH1A1 (0.46) | KDM4EALDH1A1TDP1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668224-A | TETRAALKYL- OR TRIALKYLAMMONIUM END GROUPS | BAYLOR UNIVERSITY | 1997-09-16 | — | — | US | claimed |
| US-6011133-A | Laminates of glass or metal and poly(alkylene dicarboxylates) and syntheses thereof | BAYLOR UNIVERSITY (US) | 2000-01-04 | — | — | US | disclosed |
| US-5933693-A | Electroconductive elastic member and electrophotographic apparatus using same | BRIDGESTONE CORPORATION (JP) | 1999-08-03 | — | — | US | disclosed |
| US-5911099-A | Electroconductiive member and electrophotogrpahic apparatus | BRIDGESTONE CORPORATION (JP) | 1999-06-08 | — | — | US | disclosed |
| US-5837381-A | MULTILAYER PROTECTIVE COATING; WEAR AND CORROSION RESISTANCE | UNIV BAYLOR (US) | 1998-11-17 | — | — | US | disclosed |
| US-5668224-A | TETRAALKYL- OR TRIALKYLAMMONIUM END GROUPS | BAYLOR UNIVERSITY | 1997-09-16 | — | — | US | disclosed |
| US-5451643-A | PROTECTIVE COATINGS FOR METALS OR GLASS | BAYLOR UNIVERSITY (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1994020296-A1 | POLY (ALKYLENE DICARBOXYLATES) AND SYNTHESES THEREOF | BAYLOR UNIVERSITY (US) | 1994-09-15 | — | — | WO | disclosed |
| US-4255553-A | COMPRISING A COMPOUND HAVING AT LEAST TWO EPOXY GROUPS, A POLYESTER OR ACRYLIC RESIN, AND A QUARTERNARY AMMONIUM CARBOXYLATE AS CATALYST | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1981-03-10 | — | — | US | disclosed |