Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TAS2R10 | Q9NYW0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL8092879 | 0.95 | KDM4E (0.61) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9132276 | 0.93 | TSHR (0.51) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| Benzoic Acid SCHEMBL114504 | 0.91 | TDP1 (0.61) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| Terephthalic Acid SCHEMBL8092882 | 0.91 | ALDH1A1 (0.65) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| Terephthalic Acid SCHEMBL8434829 | 0.91 | ALDH1A1 (0.65) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9134552 | 0.91 | ALDH1A1 (0.46) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9133934 | 0.91 | ALDH1A1 (0.46) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9134431 | 0.90 | ALDH1A1 (0.45) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| Benzoic Acid SCHEMBL592072 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| Aminobenzoic Acid SCHEMBL5875024 | 0.87 | KDM4E (0.52) | ALDH1A1KDM4ETDP1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5933693-A | Electroconductive elastic member and electrophotographic apparatus using same | BRIDGESTONE CORPORATION (JP) | 1999-08-03 | — | — | US | disclosed |
| US-5911099-A | Electroconductiive member and electrophotogrpahic apparatus | BRIDGESTONE CORPORATION (JP) | 1999-06-08 | — | — | US | disclosed |
| US-4255553-A | COMPRISING A COMPOUND HAVING AT LEAST TWO EPOXY GROUPS, A POLYESTER OR ACRYLIC RESIN, AND A QUARTERNARY AMMONIUM CARBOXYLATE AS CATALYST | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1981-03-10 | — | — | US | disclosed |