Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091647 | 0.98 | CCR3 (0.96) | CCR3SIGMAR1KDM4EALDH1A1KMT2A | |
| SCHEMBL11801794 | 0.94 | CCR3 (0.89) | CCR3SIGMAR1KDM4EALDH1A1KMT2A | |
| SCHEMBL6657455 | 0.92 | CCR3 (0.85) | CCR3SIGMAR1 | |
| SCHEMBL8092982 | 0.90 | SIGMAR1 (0.85) | CCR3SIGMAR1KMT2A | |
| SCHEMBL6657649 | 0.90 | CCR3 (0.82) | CCR3SIGMAR1 | |
| SCHEMBL6659913 | 0.88 | CCR3 (0.79) | CCR3SIGMAR1KDM4EALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL10502885 | 0.86 | CCR3 (0.76) | CCR3SIGMAR1 | |
| SCHEMBL2962629 | 0.86 | SIGMAR1 (1.00) | CCR3SIGMAR1 | |
| SCHEMBL6550825 | 0.86 | SIGMAR1 (1.00) | CCR3SIGMAR1 | |
| SCHEMBL9373668 | 0.85 | CCR3 (0.73) | CCR3SIGMAR1KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |