Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 18/20 | 0.59 |
| ▸ | AGTR2 | P50052 | 18/20 | 0.59 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091186 | 0.87 | AGTR1 (0.70) | AGTR1AGTR2 | |
| SCHEMBL8081222 | 0.86 | AGTR1 (0.56) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL8092921 | 0.86 | AGTR1 (0.62) | AGTR1AGTR2TLR7 | |
| SCHEMBL8094903 | 0.86 | AGTR1 (0.61) | AGTR1AGTR2 | |
| SCHEMBL8081174 | 0.85 | AGTR1 (0.57) | AGTR1AGTR2TLR7 | |
| SCHEMBL8095012 | 0.83 | AGTR1 (0.67) | AGTR1AGTR2 | |
| SCHEMBL8094791 | 0.80 | AGTR2 (0.65) | AGTR1AGTR2TLR7PDE4APDE4B | |
| SCHEMBL8094974 | 0.79 | AGTR2 (0.73) | AGTR1AGTR2 | |
| SCHEMBL8081242 | 0.79 | AGTR1 (0.66) | AGTR1AGTR2 | |
| SCHEMBL8088433 | 0.79 | AGTR1 (0.72) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |
| EP-0505893-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1992-09-30 | — | — | EP | disclosed |