Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.54 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.54 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.54 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6076785 | 0.90 | SIGMAR1 (0.63) | SIGMAR1TRPV1 | |
| SCHEMBL3566361 | 0.87 | SIGMAR1 (0.66) | SIGMAR1TRPV1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL12040578 | 0.85 | SIGMAR1 (0.64) | SIGMAR1TRPV1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL28128266 | 0.83 | SIGMAR1 (0.60) | SIGMAR1TRPV1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL4023057 | 0.83 | SIGMAR1 (0.60) | SIGMAR1 | |
| SCHEMBL14731849 | 0.82 | SIGMAR1 (0.78) | SIGMAR1 | |
| SCHEMBL9618249 | 0.82 | CYP1A2 (0.61) | SIGMAR1TRPV1 | |
| SCHEMBL4254894 | 0.81 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL18768843 | 0.79 | CYP1A2 (0.71) | SIGMAR1TRPV1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL2538905 | 0.79 | SIGMAR1 (0.95) | SIGMAR1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | disclosed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | disclosed |