Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 4/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 15/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL821997 | 0.73 | NR3C1 (0.56) | NR3C1TRPV1 | |
| SCHEMBL809096 | 0.72 | NR3C1 (1.00) | NR3C1 | |
| SCHEMBL809247 | 0.71 | NR3C1 (1.00) | NR3C1 | |
| SCHEMBL809160 | 0.69 | NR3C1 (0.89) | NR3C1TRPV1 | |
| SCHEMBL5616663 | 0.68 | NR3C1 (0.51) | NR3C1TRPV1 | |
| SCHEMBL809173 | 0.68 | NR3C1 (0.89) | NR3C1TRPV1 | |
| SCHEMBL292584 | 0.66 | NR3C1 (0.59) | NR3C1 | |
| SCHEMBL31390424 | 0.66 | NR3C1 (0.59) | NR3C1 | |
| SCHEMBL3759200 | 0.66 | NR3C1 (0.59) | NR3C1 | |
| SCHEMBL31390401 | 0.66 | NR3C1 (0.59) | NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776119-B9 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | disclosed |
| EP-1776119-B1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-01-18 | — | — | EP | disclosed |