Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 12/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5471412 | 0.86 | NR3C1 (0.57) | NR3C1PGRMEN1KMT2A | |
| SCHEMBL809302 | 0.73 | NR3C1 (0.57) | NR3C1TRPV1 | |
| SCHEMBL809123 | 0.72 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL3649830 | 0.72 | NR3C1 (0.69) | NR3C1PGRCRHR1MEN1KMT2A | |
| SCHEMBL5172786 | 0.71 | NR3C1 (0.62) | NR3C1PGR | |
| SCHEMBL2143635 | 0.71 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL809055 | 0.69 | NR3C1 (0.89) | NR3C1PGR | |
| SCHEMBL808953 | 0.67 | NR3C1 (0.89) | NR3C1PGR | |
| SCHEMBL5173892 | 0.67 | NR3C1 (0.53) | NR3C1PGRMEN1KMT2A | |
| SCHEMBL3762428 | 0.66 | NR3C1 (0.70) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776119-B9 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | claimed |
| EP-1776119-B1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-01-18 | — | — | EP | claimed |