Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.63 |
| ▸ | AR | P10275 | 2/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.63 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093207 | 1.00 | CYP19A1 (0.74) | CYP19A1ADORA3ARHSD11B1AKR1C3 | |
| SCHEMBL7032379 | 0.89 | CYP19A1 (0.74) | CYP19A1ADORA3ARHSD11B1AKR1C3 | |
| SCHEMBL7032375 | 0.89 | CYP19A1 (0.74) | CYP19A1ADORA3ARHSD11B1AKR1C3 | |
| SCHEMBL15951305 | 0.88 | CYP19A1 (0.60) | CYP19A1ADORA3ARHSD11B1AKR1C3 | |
| SCHEMBL4951987 | 0.84 | AR (0.71) | CYP19A1ADORA3ARHSD11B1AKR1C3 | |
| SCHEMBL15619210 | 0.84 | CYP19A1 (0.59) | CYP19A1ADORA3ARHSD11B1AKR1C3 | |
| SCHEMBL15619353 | 0.84 | CYP19A1 (0.59) | CYP19A1ADORA3ARHSD11B1AKR1C3 | |
| SCHEMBL8093300 | 0.81 | ADORA3 (0.68) | CYP19A1ADORA3ARHSD11B1AKR1C3 | |
| SCHEMBL8093292 | 0.81 | ADORA3 (0.68) | CYP19A1ADORA3ARHSD11B1AKR1C3 | |
| SCHEMBL28377827 | 0.79 | CYP19A1 (0.65) | CYP19A1ARMAOBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046231-A | ADMINISTERING A SUFFICIENT AMOUNT OF A CANCER CHEMOPREVENTATIVE COMPOSITION COMPRISING 4'-BROMOFLAVONE TO A MAMMAL IN NEED TO PREVENT, DELAY OR REVERSE A CANCER SENSITIVE TO 4'-BROMOFLAVONE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2000-04-04 | — | — | US | disclosed |