SCHEMBL8093250

SCHEMBL8093250

c1ccc2c(CNNC3CCCCCC3)cccc2c1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 2/20 0.52
CXCR4 P61073 1/20 0.44
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
ACHE P22303 2/20 0.43
CA2 P00918 1/20 0.43
TSHR P16473 1/20 0.43
SIGMAR1 Q99720 2/20 0.42
MAPT P10636 1/20 0.42
LMNA P02545 2/20 0.41
HTT P42858 2/20 0.41
SLC18A2 Q05940 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10433983 0.84 KMT2A (0.57) EPHX1CXCR4KMT2AMEN1KDM4E
Hydrochloric Acid SCHEMBL10433976 0.83 KMT2A (0.56) EPHX1CXCR4KMT2AMEN1KDM4E
SCHEMBL15492796 0.82 HTT (0.55) EPHX1CXCR4KMT2AMEN1KDM4E
SCHEMBL13771635 0.77 EPHX1 (0.48) EPHX1KMT2AACHECA2TSHR
SCHEMBL9227710 0.76 KMT2A (0.52) EPHX1CXCR4KMT2AMEN1KDM4E
SCHEMBL2752183 0.76 EPHX1 (0.67) EPHX1KMT2AMEN1KDM4EALDH1A1
SCHEMBL13779439 0.76 MEN1 (0.67) EPHX1KMT2AMEN1KDM4EALDH1A1
SCHEMBL15805488 0.76 ACHE (0.46) EPHX1ACHECA2TSHRSLC18A2
SCHEMBL2730868 0.75 ACHE (0.49) EPHX1KMT2AACHECA2TSHR
SCHEMBL2751915 0.74 SIGMAR1 (0.67) EPHX1KMT2AMEN1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 EP disclosed
EP-0946549-A1 COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1999-10-06 EP disclosed
WO-1999031506-A9 PARALLEL SOLUTION PHASE SYNTHESIS OF LACTAMS LILLY CO ELI (US) 1999-09-16 WO disclosed
WO-1999031506-A1 PARALLEL SOLUTION PHASE SYNTHESIS OF LACTAMS ELI LILLY AND COMPANY (US) 1999-06-24 WO disclosed
WO-1999031507-A1 PEPTIDOMIMETIC TEMPLATE-BASED COMBINATORIAL LIBRARIES ELI LILLY AND COMPANY (US) 1999-06-24 WO disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed
WO-1998027087-A1 COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-06-25 WO disclosed