Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RGS12 | O14924 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081967 | 0.93 | EGFR (0.58) | EGFRERBB2PRMT5 | |
| SCHEMBL8560764 | 0.83 | ERBB2 (0.72) | EGFRERBB2MEN1GMNNALDH1A1 | |
| SCHEMBL8096166 | 0.81 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL9910675 | 0.80 | EGFR (0.84) | EGFRERBB2ERBB4 | |
| SCHEMBL19911584 | 0.78 | GRM2 (0.66) | ALDH1A1MAPTHPGDRAB9ATDP1 | |
| SCHEMBL8556365 | 0.77 | ERBB2 (0.69) | EGFRERBB2MEN1GMNNALDH1A1 | |
| SCHEMBL29690398 | 0.74 | EGFR (1.00) | EGFRERBB2LMNARAF1CYP1A2 | |
| SCHEMBL30513 | 0.74 | EGFR (1.00) | EGFRERBB2LMNARAF1CYP1A2 | |
| SCHEMBL6883721 | 0.74 | ERBB2 (0.76) | EGFRERBB2PRMT5MEN1RGS12 | |
| SCHEMBL9910666 | 0.74 | EGFR (0.66) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |