Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 6/20 | 0.72 |
| ▸ | EGFR | P00533 | 12/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 3/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556365 | 0.92 | ERBB2 (0.69) | ERBB2EGFRKDRRETLCK | |
| SCHEMBL8555349 | 0.84 | ERBB2 (1.00) | ERBB2EGFRKDRRETLMNA | |
| SCHEMBL8093486 | 0.83 | EGFR (0.57) | ERBB2EGFRLMNAMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL31681715 | 0.83 | ERBB2 (0.98) | ERBB2EGFRKDRRETLCK | |
| SCHEMBL8555957 | 0.81 | ERBB2 (0.71) | ERBB2EGFRKDRRETLCK | |
| SCHEMBL8556847 | 0.81 | ERBB2 (1.00) | ERBB2EGFRKDRRETLCK | |
| Hydrochloric Acid SCHEMBL8596174 | 0.80 | ERBB2 (0.98) | ERBB2EGFRKDRRETLCK | |
| SCHEMBL8595567 | 0.79 | ERBB2 (0.86) | ERBB2EGFRKDRRETLCK | |
| SCHEMBL1387156 | 0.78 | EGFR (0.75) | ERBB2EGFRKDRRETLCK | |
| Hydrochloric Acid SCHEMBL8558936 | 0.78 | ERBB2 (0.84) | ERBB2EGFRKDRRETLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | claimed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | claimed |
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |