Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 8/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081976 | 0.92 | CSNK2A1 (0.46) | CSNK2A1EGFRSYK | |
| SCHEMBL8082010 | 0.84 | SYK (0.46) | CSNK2A1EGFRSYKTGFBR1FLT1 | |
| SCHEMBL8096183 | 0.84 | MKNK1 (0.47) | EGFRSYKTGFBR1NPC1RAB9A | |
| SCHEMBL8524532 | 0.80 | SYK (0.46) | SYKKDRNPC1RAB9AMAPT | |
| SCHEMBL3265691 | 0.80 | MAPT (0.44) | CSNK2A1TGFBR1FLT1KDRMAPT | |
| SCHEMBL2991831 | 0.78 | DYRK1A (0.47) | CSNK2A1EGFRKDRERBB2 | |
| SCHEMBL2992809 | 0.78 | AURKA (0.46) | CSNK2A1EGFRSYKKDRERBB2 | |
| SCHEMBL8147977 | 0.75 | SCN9A (0.50) | CSNK2A1EGFRSYKKDRERBB2 | |
| SCHEMBL6584052 | 0.75 | KDM1A (0.45) | EGFRTGFBR1MAPT | |
| SCHEMBL4867963 | 0.75 | AURKA (0.48) | CSNK2A1EGFRKDRPDGFRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |