Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524532 | 0.92 | SYK (0.46) | ROCK2ROCK1SYKJAK3NPC1 | |
| SCHEMBL3584760 | 0.85 | ROCK2 (0.60) | MKNK1ROCK2ROCK1SYKJAK3 | |
| SCHEMBL8093515 | 0.84 | CSNK2A1 (0.46) | SYKEGFRTGFBR1NPC1RAB9A | |
| SCHEMBL8081976 | 0.80 | CSNK2A1 (0.46) | SYKEGFRJAK2 | |
| SCHEMBL3265691 | 0.79 | MAPT (0.44) | TGFBR1JAK2 | |
| SCHEMBL2991831 | 0.77 | DYRK1A (0.47) | EGFRJAK2 | |
| SCHEMBL2992809 | 0.77 | AURKA (0.46) | SYKEGFR | |
| SCHEMBL8147977 | 0.74 | SCN9A (0.50) | SYKEGFR | |
| SCHEMBL13316077 | 0.74 | ROCK2 (0.65) | ROCK2ROCK1TGFBR1NPC1RAB9A | |
| SCHEMBL4867963 | 0.74 | AURKA (0.48) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |