Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 4/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093515 | 0.84 | CSNK2A1 (0.46) | SYKEGFRCSNK2A1ERBB2FLT1 | |
| SCHEMBL2998232 | 0.78 | EGFR (0.46) | EGFRCSNK2A1ERBB2 | |
| SCHEMBL2986229 | 0.78 | AURKA (0.45) | SYKEGFRCSNK2A1ERBB2KDR | |
| SCHEMBL8490286 | 0.77 | KMT2A (0.40) | SYKEGFRCSNK2A1KDR | |
| SCHEMBL8081976 | 0.76 | CSNK2A1 (0.46) | SYKEGFRCSNK2A1 | |
| SCHEMBL8096003 | 0.75 | KDM4C (0.38) | SYKEGFRERBB2PDGFRBMAPT | |
| SCHEMBL8093494 | 0.75 | XDH (0.33) | ERBB2PDGFRBKDRNPC1MAPT | |
| SCHEMBL8096183 | 0.71 | MKNK1 (0.47) | SYKEGFRTGFBR1NPC1RAB9A | |
| SCHEMBL8150757 | 0.71 | PDE7A (0.38) | EGFRCSNK2A1ERBB2KDRNPC1 | |
| SCHEMBL8487402 | 0.70 | EGFR (0.30) | EGFRCSNK2A1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |