Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.46 |
| ▸ | MTOR | P42345 | 12/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083924 | 0.95 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPIK3CDATM | |
| SCHEMBL8083160 | 0.91 | PIK3CD (0.43) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8083867 | 0.88 | PIK3CA (0.52) | PIK3CAMTORPIK3CGPIK3CDATM | |
| SCHEMBL8090158 | 0.87 | MTOR (0.46) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8096190 | 0.86 | PIK3CA (0.50) | PIK3CAMTORPIK3CGPIK3CDATM | |
| SCHEMBL8098775 | 0.85 | CA1 (0.43) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL3931995 | 0.85 | PIK3CA (0.65) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8092289 | 0.83 | CA1 (0.41) | PIK3CAMTORPIK3CD | |
| SCHEMBL8092236 | 0.83 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8096186 | 0.82 | MAPT (0.41) | PIK3CAPIK3CDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |