Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083160 | 0.88 | PIK3CD (0.43) | MTORPIK3CAPIK3CGPIK3CDCA12 | |
| SCHEMBL8093573 | 0.87 | PIK3CA (0.46) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL8092043 | 0.86 | MTOR (0.49) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL8092637 | 0.86 | KMT2A (0.42) | MTORPIK3CAPIK3CGPIK3CDCA12 | |
| SCHEMBL8097257 | 0.86 | ALDH1A1 (0.41) | MTORPIK3CAPIK3CGALDH1A1CA12 | |
| SCHEMBL8083973 | 0.85 | ALDH1A1 (0.43) | MTORPIK3CAPIK3CGPIK3CDALDH1A1 | |
| SCHEMBL8090246 | 0.85 | PIK3CA (0.42) | MTORPIK3CAPIK3CGPIK3CDALDH1A1 | |
| SCHEMBL8094423 | 0.84 | CA2 (0.43) | MTORPIK3CAPIK3CGALDH1A1CA12 | |
| SCHEMBL8083874 | 0.84 | MTOR (0.47) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL8099749 | 0.84 | MTOR (0.40) | MTORPIK3CAPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |