Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.47 |
| ▸ | RARG | P13631 | 5/20 | 0.47 |
| ▸ | RARA | P10276 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101333 | 0.93 | RARB (0.47) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL7793994 | 0.88 | RXRA (0.47) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL6734666 | 0.88 | RARB (0.48) | RARBRARGRARASMN1; SMN2KDM4E | |
| SCHEMBL6734636 | 0.87 | CYP3A4 (0.51) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL7800004 | 0.81 | RXRA (0.47) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL6729936 | 0.79 | CYP3A4 (0.49) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8094176 | 0.79 | RARB (0.48) | RARBRARGRARASMN1; SMN2KDM4E | |
| SCHEMBL29595859 | 0.79 | RARB (0.52) | RARBRARGRARASMN1; SMN2KDM4E | |
| SCHEMBL20887637 | 0.79 | RARB (0.52) | RARBRARGRARASMN1; SMN2KDM4E | |
| SCHEMBL7794100 | 0.78 | ALDH1A1 (0.37) | RARBRARGRARACYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030952-A | AS HUMAN AND VETERINARY MEDICINE, PARTICULARLY IN THE TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGIC CONDITIONS, AND IN COSMETIC COMPOSITIONS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIOUES GALDERMA (FR) | 2000-02-29 | — | — | US | disclosed |