Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.69 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.69 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.69 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | PPARD | Q03181 | 6/20 | 0.50 |
| ▸ | PPARA | Q07869 | 6/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28778353 | 0.96 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL28106104 | 0.96 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL6330595 | 0.96 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL28754734 | 0.93 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL9391851 | 0.93 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL2305655 | 0.93 | LMNA (0.61) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL28184121 | 0.88 | LMNA (0.75) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL15323174 | 0.87 | LMNA (0.53) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Succinic Acid SCHEMBL28454927 | 0.87 | LMNA (0.55) | LMNAEGLN1ALKBH5SUCNR1FFAR3 | |
| Levulinic Acid SCHEMBL27736725 | 0.87 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157348-A1 | COMPOSITIONS AND METHODS FOR TREATING MORPHINE, HEROIN, AND ALCOHOL DEPENDENCE | Behnam, Babak (US) | 2023-04-05 | — | — | EP | claimed |
| CN-114588272-A | NO-loaded docetaxel nano-drug and preparation method and application thereof | 皖西学院 | 2022-06-07 | — | — | CN | claimed |
| CN-107382728-A | 2 (3,4 dihydroxy phenyl) ethanol succinates and its extracting method and application | 大理大学 | 2017-11-24 | — | — | CN | claimed |
| CN-105244165-A | Chip type high-voltage aluminum electrolytic capacitor, electrolyte thereof and preparation method of electrolyte | FENGHUA ADVANCED TECHNOLOGY HOLDING CO LTD | 2016-01-13 | — | — | CN | claimed |
| US-20150133577-A1 | VINYL ACETATE-ETHYLENE COPOLYMER EMULSION AND PAPER COATING COMPOSITION BASED ON THE SAME | CELANESE INTERNATIONAL CORPORATION (US) | 2015-05-14 | — | — | US | claimed |
| EP-2850141-A1 | VINYL ACETATE-ETHYLENE COPOLYMER EMULSION AND PAPER COATING COMPOSITION BASED ON THE SAME | Celanese International Corporation (US) | 2015-03-25 | — | — | EP | claimed |
| CN-103694238-A | NO donor type matrine derivative and preparation method and medical application thereof | HE LIQIN | 2014-04-02 | — | — | CN | claimed |
| WO-2013170411-A1 | VINYL ACETATE-ETHYLENE COPOLYMER EMULSION AND PAPER COATING COMPOSITION BASED ON THE SAME | CELANESE INTERNATIONAL CORPORATION (US) | 2013-11-21 | — | — | WO | claimed |
| WO-2013113152-A1 | VINYL ACETATE-ETHYLENE COPOLYMER EMULSION AND POLYMER CEMENT WATERPROOF COMPOSITION BASED ON THE SAME | CELANESE INTERNATIONAL CORPORATION (US) | 2013-08-08 | — | — | WO | claimed |
| CN-116891458-A | Preparation method of ilaprazole | 南京唯创远医药科技有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116356562-A | Low-oil consumption polyester FDY spinning oil for WINGS equipment and preparation method thereof | 浙江恒逸石化研究院有限公司 | 2023-06-30 | — | — | CN | disclosed |
| US-20230190904-A1 | Compositions and Methods for Treating Morphine, Heroin, and Alcohol Dependence | Behnam, Babak (US) | 2023-06-22 | — | — | US | disclosed |
| EP-4157348-A1 | COMPOSITIONS AND METHODS FOR TREATING MORPHINE, HEROIN, AND ALCOHOL DEPENDENCE | Behnam, Babak (US) | 2023-04-05 | — | — | EP | disclosed |
| US-11572564-B2 | Microorganisms for producing 1,4-butanediol and methods related thereto | GENOMATICA, INC. (US) | 2023-02-07 | — | — | US | disclosed |
| WO-2003095665-A2 | PMEA AND PMPA CYCLIC PRODUCING SYNTHESIS | METABASIS THERAPEUTICS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |
| US-20030162832-A1 | L-DOPA ethyl ester salts and uses thereof | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2003-08-28 | — | — | US | disclosed |
| WO-2003041646-A2 | L-DOPA ETHYL ESTER SALTS AND USES THEREOF | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2003-05-22 | — | — | WO | disclosed |
| CN-1395923-A | Application of xanthiphenylketamine or its salt in preparing medicines to treat cardiovascalar disease | ZHONGWEI BIOTECHNOLOGY CO LTD (CN) | 2003-02-12 | — | — | CN | disclosed |
| WO-2002069949-A2 | COMBINATION THERAPY FOR REDUCTION OF TOXYCITY OF CHEMOTHERAPEUTIC AGENTS | PRENDERGAST PATRICK T (IE) | 2002-09-12 | — | — | WO | disclosed |
| CN-1365273-A | Percutaneous administration preparations | KAO CORP (JP) | 2002-08-21 | — | — | CN | disclosed |