Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 10/20 | 0.50 |
| ▸ | CNR2 | P34972 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101771 | 0.91 | PTGS2 (0.54) | CNR1CNR2PTGS2 | |
| SCHEMBL8093987 | 0.90 | PTGS2 (0.48) | CNR1CNR2CA1CA2CA7 | |
| SCHEMBL8085724 | 0.86 | PTGS2 (0.51) | CNR1CNR2CA1CA2CA7 | |
| SCHEMBL8095797 | 0.84 | CNR1 (0.69) | CNR1CNR2CA1CA2CA7 | |
| SCHEMBL8092536 | 0.84 | PTGS2 (0.43) | CNR1CNR2CA1CA2CA13 | |
| SCHEMBL8086911 | 0.83 | HPGD (0.45) | CNR1CNR2CA1CA2PTGS2 | |
| SCHEMBL8086615 | 0.83 | PTGS2 (0.49) | CNR1CNR2CA1CA2PTGS2 | |
| SCHEMBL8099660 | 0.82 | MAPT (0.49) | CNR1CA1CA2CA7PTGS2 | |
| SCHEMBL8094849 | 0.82 | HPGD (0.48) | CA1CA2CA7CA13PTGS2 | |
| SCHEMBL8099266 | 0.80 | PTGS2 (0.53) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |