Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 6/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8094421 | 0.91 | PIK3CA (0.38) | CXCR2PIK3CAMTORPIK3CGFPR2 | |
| SCHEMBL8084462 | 0.90 | FPR2 (0.37) | CXCR2PIK3CAFPR2SCN9AMAPT | |
| SCHEMBL8091932 | 0.89 | FPR2 (0.40) | CXCR2PIK3CAMTORPIK3CGFPR2 | |
| SCHEMBL8090843 | 0.85 | PIK3CA (0.45) | PIK3CAMTORPIK3CGFPR2SCN9A | |
| SCHEMBL8097581 | 0.82 | MAPT (0.38) | PIK3CAMAPTKDM4EHTTPIK3CD | |
| SCHEMBL8090246 | 0.82 | PIK3CA (0.42) | PIK3CAMTORPIK3CGMAPTKDM4E | |
| SCHEMBL8098657 | 0.79 | MAPT (0.37) | PIK3CAMAPTKDM4EHTTPIK3CD | |
| SCHEMBL8098658 | 0.79 | MAPT (0.37) | PIK3CAMAPTKDM4EHTTPIK3CD | |
| SCHEMBL8096342 | 0.79 | PIK3CA (0.41) | PIK3CAMTORPIK3CGMAPTKDM4E | |
| SCHEMBL8091933 | 0.78 | FPR2 (0.39) | PIK3CAMTORPIK3CGFPR2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |