Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | PRF1 | P14222 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.33 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13028219 | 0.79 | GAA (0.41) | LMNAPKMPTK2PRF1CYP11B1 | |
| SCHEMBL2892914 | 0.72 | GAA (0.41) | LMNAPKMPTK2PRF1CYP11B1 | |
| SCHEMBL5033855 | 0.71 | LMNA (0.44) | LMNAPKMPTK2PRF1CYP11B1 | |
| SCHEMBL10053578 | 0.71 | LMNA (0.50) | LMNAPKMPTK2PRF1CYP11B1 | |
| SCHEMBL5027379 | 0.69 | LMNA (0.42) | LMNAPKMPTK2PRF1CYP11B1 | |
| SCHEMBL15382509 | 0.69 | PRF1 (0.43) | LMNAPKMPTK2PRF1CYP11B1 | |
| SCHEMBL16202087 | 0.68 | LMNA (0.47) | LMNAPKMPTK2CYP11B1CYP11B2 | |
| SCHEMBL5033854 | 0.67 | MYC (0.46) | LMNAPKMPRF1MAP4K4IMPDH2 | |
| SCHEMBL13267180 | 0.64 | LMNA (0.43) | LMNAPKMPTK2PRF1CYP11B1 | |
| SCHEMBL2889950 | 0.64 | IMPDH2 (0.35) | LMNAPKMPRF1MAP4K4IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017818-A1 | HETEROCYCLE-ARYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-02-05 | — | — | WO | disclosed |