Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11006102 | 0.82 | KDM4E (0.69) | PTGS2MEN1KMT2AKDM4EGALR3 | |
| SCHEMBL10515613 | 0.81 | GCGR (0.53) | PTGS2MAPK14MEN1KMT2AKDM4E | |
| SCHEMBL8092522 | 0.81 | GCGR (0.53) | PTGS2MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL10517374 | 0.81 | PTGS2 (0.47) | PTGS2MAPK14MEN1KMT2AKDM4E | |
| SCHEMBL7407595 | 0.79 | KDM4E (0.73) | PTGS2MEN1KMT2AKDM4EGALR3 | |
| SCHEMBL8085712 | 0.78 | PTGS2 (0.63) | PTGS2MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL8101156 | 0.78 | PTGS2 (0.63) | PTGS2MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL10740403 | 0.78 | PTGS2 (1.00) | PTGS2MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL7981809 | 0.78 | PTGS2 (0.77) | PTGS2MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL11004018 | 0.78 | PDE3A (0.67) | PTGS2MEN1KMT2AKDM4EGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |