Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8094377 | 0.85 | EGFR (0.47) | KDM4EHPGDGALR3ALDH1A1GAA | |
| SCHEMBL10515613 | 0.82 | GCGR (0.53) | GCGRMAPK14PTGS2KDM4EHPGD | |
| SCHEMBL10517374 | 0.82 | PTGS2 (0.47) | GCGRMAPK14PTGS2KDM4EHPGD | |
| SCHEMBL8094625 | 0.81 | PTGS2 (0.72) | MAPK14PTGS2KDM4EHPGDGALR3 | |
| SCHEMBL11003142 | 0.80 | KDM4E (0.69) | KDM4EHPGDGALR3ALDH1A1GAA | |
| SCHEMBL10514748 | 0.78 | GCGR (0.53) | GCGRMAPK14PTGS2KDM4EPTGS1 | |
| SCHEMBL7407595 | 0.77 | KDM4E (0.73) | PTGS2KDM4EHPGDGALR3ALDH1A1 | |
| SCHEMBL11002221 | 0.77 | PDE3A (0.68) | KDM4EHPGDGALR3ALDH1A1GAA | |
| SCHEMBL19835567 | 0.76 | MCL1 (0.55) | GCGRMAPK14KDM4EHPGDGALR3 | |
| SCHEMBL12427051 | 0.75 | HPGD (0.69) | KDM4EHPGDGALR3ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |