SCHEMBL809463

SCHEMBL809463

Cc1cc(C(C)c2cc(C)cc(C(C)(C)C)c2C=CC(=O)O)c(O)c(C(C)(C)C)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.42
ALDH1A1 P00352 2/20 0.42
CA2 P00918 1/20 0.42
POLB P06746 1/20 0.42
TYR P14679 1/20 0.42
GABBR2 O75899 2/20 0.39
GABBR1 Q9UBS5 2/20 0.39
HSPA5 P11021 1/20 0.37
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
HIF1A Q16665 2/20 0.36
TNFRSF1A P19438 1/20 0.36
GLRA3 O75311 1/20 0.36
GLRB P48167 1/20 0.36
PTGS1 P23219 2/20 0.35
PTGS2 P35354 2/20 0.35
CYP2D6 P10635 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GPR55 Q9Y2T6 1/20 0.33
PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7200424 0.93 SMN1; SMN2 (0.45) SMN1; SMN2ALDH1A1CA2POLBTYR
SCHEMBL809386 0.87 CYP1A2 (0.44) SMN1; SMN2ALDH1A1GABBR2GABBR1CYP2C9
SCHEMBL4157787 0.86 CYP1A2 (0.39) SMN1; SMN2ALDH1A1GABBR2GABBR1CYP2C9
SCHEMBL4153743 0.85 CYP2C9 (0.42) SMN1; SMN2ALDH1A1CA2POLBTYR
SCHEMBL4158422 0.82 GAA (0.39) SMN1; SMN2ALDH1A1GABBR2GABBR1HSPA5
SCHEMBL225440 0.80 SMN1; SMN2 (0.65) SMN1; SMN2ALDH1A1CA2POLBTYR
SCHEMBL29463589 0.80 SMN1; SMN2 (0.65) SMN1; SMN2ALDH1A1CA2POLBTYR
SCHEMBL7200672 0.80 CYP3A4 (0.37) SMN1; SMN2ALDH1A1GABBR2GABBR1CYP2C9
SCHEMBL4220907 0.80 SMN1; SMN2 (0.49) SMN1; SMN2ALDH1A1CA2POLBTYR
SCHEMBL7203636 0.76 PTGS2 (0.39) SMN1; SMN2ALDH1A1CA2GABBR2GABBR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1326915-B1 POLYOLEFIN ARTICLES WITH LONG-TERM ELEVATED TEMPERATURE STABILITY CLARIANT FINANCE BVI LTD (VG) 2005-11-09 EP claimed
EP-3331945-B1 PIPE FOR THE TRANSPORT OF WATER HAVING IMPROVED RESISTANCE TO CHLORINATED DISINFECTANTS SABIC GLOBAL TECHNOLOGIES BV (NL) 2020-10-07 EP disclosed
EP-3331945-A1 PIPE FOR THE TRANSPORT OF WATER HAVING IMPROVED RESISTANCE TO CHLORINATED DISINFECTANTS SABIC Global Technologies B.V. (NL) 2018-06-13 EP disclosed
WO-2017021124-A1 PIPE FOR THE TRANSPORT OF WATER HAVING IMPROVED RESISTANCE TO CHLORINATED DISINFECTANTS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2017-02-09 WO disclosed
EP-1666535-B1 RESIN COMPOSITION AND COMPOSITE USING THE COMPOSITION AND PRODUCTION PROCESS THEREOF DAICEL EVONIK LTD (JP) 2015-11-04 EP disclosed
US-8536258-B2 Stabilizer and method of manufacturing the same, thermoplastic polymer composition using the same, and method of stabilizing thermoplastic polymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-09-17 US disclosed
EP-2017299-B1 Stabilizer and method of manufacturing the same, thermoplastic polymer composition using the same, and method of stabilizing thermoplastic polymer SUMITOMO CHEMICAL CO (JP) 2011-11-23 EP disclosed
US-7989540-B2 Resin composition and composite using the composition and production process thereof DAICEL-EVONIK LTD. (JP) 2011-08-02 US disclosed
US-20090030127-A1 Stabilizer and method of manufacturing the same, thermoplastic polymer composition using the same, and method of stabilizing thermoplastic polymer SUMITOMO CHEMICAL COMPANY, LIMITED 2009-01-29 US disclosed
EP-2017299-A1 Stabilizer and method of manufacturing the same, thermoplastic polymer composition using the same, and method of stabilizing thermoplastic polymer Sumitomo Chemical Company, Limited (JP) 2009-01-21 EP disclosed
US-20070292703-A1 Resin Composition and Composite Using the Composition and Production Process Thereof DAICEL-DEGUSSA LTD. (JP) 2007-12-20 US disclosed
EP-1666535-A1 RESIN COMPOSITIONS, COMPOSITES MADE BY USING THE SAME, AND PROCESS FOR PRODUCTION THEREOF Daicel-Degussa Ltd. (JP) 2006-06-07 EP disclosed