Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 7/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | RARB | P10826 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102366 | 0.93 | TP53 (0.59) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL17652958 | 0.82 | L3MBTL1 (0.47) | TSHRTP53PLA2G4BL3MBTL1 | |
| SCHEMBL11296001 | 0.80 | MEN1 (0.47) | PKMMAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL13653529 | 0.79 | L3MBTL1 (0.66) | TSHRTP53PLA2G4BHTTALDH1A1 | |
| SCHEMBL8668415 | 0.78 | ALDH1A1 (0.50) | TP53PLA2G4BRARBALDH1A1 | |
| SCHEMBL175191 | 0.77 | TP53 (0.77) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL10798086 | 0.77 | TP53 (0.89) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL736876 | 0.77 | TP53 (0.89) | TSHRTP53PLA2G4BPKMMAPK1 | |
| SCHEMBL6775355 | 0.76 | PSEN1 (0.42) | TSHRPKM | |
| SCHEMBL177390 | 0.76 | PLA2G4B (0.82) | TSHRTP53PLA2G4BPKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604657-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2000-01-12 | — | — | EP | disclosed |
| US-5376665-A | Antidiabetic agent, hypoglycemic agent | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1994-12-27 | — | — | US | disclosed |
| EP-0604657-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1994-07-06 | — | — | EP | disclosed |