Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 6/20 | 0.44 |
| ▸ | FAAH | O00519 | 8/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108442 | 1.00 | MAPT (0.44) | MAPTRXFP1NAAAFAAHALOX5 | |
| SCHEMBL8104160 | 0.95 | HDAC3 (0.42) | NAAAFAAHHDAC1HDAC2 | |
| SCHEMBL8094868 | 0.90 | HMOX1 (0.42) | FAAHALOX5 | |
| SCHEMBL8438972 | 0.87 | MAPT (0.43) | MAPTRXFP1NAAAFAAHALOX5 | |
| SCHEMBL8102640 | 0.83 | TRPV1 (0.51) | — | |
| SCHEMBL8110096 | 0.81 | SIGMAR1 (0.48) | FAAH | |
| SCHEMBL8104121 | 0.80 | MAPT (0.43) | MAPTRXFP1NAAAFAAHALOX5 | |
| SCHEMBL8110094 | 0.80 | MAPT (0.43) | MAPTRXFP1NAAAFAAHALOX5 | |
| SCHEMBL8443320 | 0.80 | ACE (0.42) | MAPTRXFP1HDAC1HDAC2 | |
| SCHEMBL8104122 | 0.79 | MAPT (0.43) | MAPTRXFP1NAAAFAAHALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | claimed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | claimed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |