Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095359 | 1.00 | HTR2C (0.55) | HTR2CHTR2AHTR2BKDM1AMTNR1A | |
| SCHEMBL8104287 | 0.86 | HTR2C (0.52) | HTR2CHTR2AHTR2BKDM1AMTNR1A | |
| SCHEMBL8104288 | 0.86 | HTR2C (0.52) | HTR2CHTR2AHTR2BKDM1AMTNR1A | |
| SCHEMBL8098498 | 0.84 | HTR2C (0.56) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| SCHEMBL8098497 | 0.84 | HTR2C (0.56) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| SCHEMBL8098175 | 0.84 | MTNR1B (0.51) | HTR2CHTR2AHTR2BKDM1AMTNR1A | |
| SCHEMBL8098179 | 0.84 | MTNR1B (0.51) | HTR2CHTR2AHTR2BKDM1AMTNR1A | |
| SCHEMBL8102597 | 0.83 | HTR2C (0.56) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| SCHEMBL8102591 | 0.83 | HTR2C (0.56) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| SCHEMBL4126434 | 0.82 | HTR2A (0.51) | HTR2CHTR2AHTR2BKDM1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |