SCHEMBL8095617

SCHEMBL8095617

C[C@@](O)(CC(=O)O)C(F)(F)F

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 0.55
CHRM1 P11229 1/20 0.55
TBXA2R P21731 1/20 0.55
ADRA1A P35348 1/20 0.55
CYP2C19 P33261 2/20 0.46
HIF1A Q16665 2/20 0.46
TSHR P16473 2/20 0.46
CYP2D6 P10635 1/20 0.46
ACLY P53396 3/20 0.44
ALDH1A1 P00352 2/20 0.42
CPT2 P23786 2/20 0.41
KDM4E B2RXH2 1/20 0.41
FFAR1 O14842 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
TET2 Q6N021 2/20 0.35
POLB P06746 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27553894 1.00 HMGCR (0.55) HMGCRCHRM1TBXA2RADRA1ACYP2C19
SCHEMBL936633 1.00 HMGCR (0.55) HMGCRCHRM1TBXA2RADRA1ACYP2C19
SCHEMBL14448847 0.79 HMGCR (0.36) HMGCRCHRM1TBXA2RADRA1ATSHR
SCHEMBL16752633 0.78 HMGCR (0.60) HMGCRCHRM1TBXA2RADRA1ACYP2C19
SCHEMBL3188769 0.77 HTT (0.35) HMGCRCHRM1TBXA2RADRA1ATSHR
SCHEMBL14357445 0.77 FAAH (0.38) HMGCRCHRM1TBXA2RADRA1ANPSR1
SCHEMBL27983637 0.77 HMGCR (0.36) HMGCRCHRM1TBXA2RADRA1ACYP2C19
SCHEMBL21272585 0.77 HMGCR (0.46) HMGCRCHRM1TBXA2RADRA1ACYP2C19
SCHEMBL19214603 0.77 PAM (0.39) HMGCRCHRM1TBXA2RADRA1ACYP2C19
SCHEMBL11042733 0.76 HMGCR (0.57) HMGCRCHRM1TBXA2RADRA1ACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025090480-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-05-01 WO disclosed
WO-2025090465-A1 HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-05-01 WO disclosed
US-6043385-A TREATMENT OF PSORIASIS, BASAL CELL CARCINOMAS, DISORDERS OF KERATINIZATION AND KERATOSIS, NEOPLASTIC DISEASES SUCH AS LEUKEMIA, DISORDERS OF THE SEBACEOUS GLANDS SUCH AS ACNE AND SEBORRHOIC DERMATITIS, OSTEOPOROSIS, HYPERPARATHYROIDISM HOFFMAN-LA ROCHE INC. (US) 2000-03-28 US disclosed
WO-1999031055-A1 NOVEL VITAMIN D3 AMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-06-24 WO disclosed