Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3056259 | 0.82 | USP30 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3040146 | 0.80 | PSEN1 (0.41) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3045214 | 0.80 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3056041 | 0.75 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3040182 | 0.74 | CYP1A2 (0.55) | NR2E1CYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL3055463 | 0.74 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27819262 | 0.73 | GAA (0.48) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3050264 | 0.71 | CYP2E1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1616168 | 0.70 | ALDH1A1 (0.49) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23119173 | 0.68 | LMNA (0.41) | NR2E1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156580-A1 | TRIAZOLE DERIVATIVES FOR TREATING ALZHEIMER'S DISEASE AND RELATED CONDITIONS | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |