SCHEMBL8096006

SCHEMBL8096006

CCCCC[SiH]1CCC(CCc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)CC1

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.43
FDFT1 P37268 2/20 0.36
TAAR1 Q96RJ0 1/20 0.35
MMP2 P08253 1/20 0.34
MMP3 P08254 1/20 0.34
MAOA P21397 1/20 0.34
TLR8 Q9NR97 1/20 0.34
CHKA P35790 1/20 0.33
CNR2 P34972 1/20 0.33
KIF11 P52732 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8096004 1.00 MAOB (0.43) MAOBFDFT1TAAR1MMP2MMP3
SCHEMBL8032552 0.96 MAOB (0.45) MAOBTAAR1MAOA
SCHEMBL8032550 0.96 MAOB (0.45) MAOBTAAR1MAOA
SCHEMBL7771579 0.88 MAOB (0.40) MAOBMAOA
SCHEMBL7771574 0.88 MAOB (0.40) MAOBMAOA
SCHEMBL8098796 0.85 GRM2 (0.37)
SCHEMBL8098792 0.85 GRM2 (0.37)
SCHEMBL9809515 0.84 MAOB (0.48) MAOBFDFT1TAAR1MMP2MMP3
SCHEMBL8019187 0.84 MAOB (0.42) MAOBFDFT1TAAR1MAOACHKA
SCHEMBL8019185 0.84 MAOB (0.42) MAOBFDFT1TAAR1MAOACHKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0668286-B1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 2000-12-20 EP disclosed
US-5523440-A Silacyclohexane compound, a method of preparaing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-04 US disclosed
EP-0668286-A1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-08-23 EP disclosed