Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | CD69 | Q07108 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL914222 | 0.92 | NOTUM (0.38) | SRD5A2CD69MAOAHDAC4HDAC7 | |
| SCHEMBL10476775 | 0.89 | MAOA (0.39) | MAOAALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL36333 | 0.89 | MAOA (0.39) | MAOAALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL9160477 | 0.89 | MAOA (0.39) | MAOAALDH1A1KDM4ELMNACYP1A2 | |
| Benzophenone SCHEMBL152952 | 0.89 | ALDH1A1 (0.50) | SRD5A2ALDH1A1LMNACA2CA4 | |
| Hydrochloric Acid SCHEMBL585839 | 0.87 | MAOA (0.37) | MAOAALDH1A1KDM4ELMNACYP1A2 | |
| Ammonia Solution, Strong SCHEMBL1871983 | 0.87 | MAOA (0.37) | MAOAALDH1A1KDM4ELMNACYP1A2 | |
| Methacrylic Acid SCHEMBL16508022 | 0.86 | NOTUM (0.34) | SRD5A2CD69MAOAALDH1A1KDM4E | |
| Acetophenone SCHEMBL10711564 | 0.86 | MAPT (0.43) | SRD5A2ALDH1A1LMNACES2CES1 | |
| Ethylene SCHEMBL9721427 | 0.85 | MAOA (0.36) | MAOACYP1A2MAOBCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104910131-A | New thioxanthone carboxylic ester photoinitiator and preparation method thereof | TIANJIN JIURI CHEMICAL CO LTD | 2015-09-16 | — | — | CN | disclosed |
| US-6025408-A | Liquid thioxanthone photoinitiators | FIRST CHEMICAL CORPORATION (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1998042697-A2 | LIQUID THIOXANTHONE PHOTOINITIATORS | FIRST CHEMICAL CORPORATION (US) | 1998-10-01 | — | — | WO | disclosed |
| US-5248805-A | Radiation-senstive, ethylenically unsaturated, copolymerizable compounds and their preparation | BASF AKTIENGESELLSCHAFT (DE) | 1993-09-28 | — | — | US | disclosed |