Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 12/20 | 0.83 |
| ▸ | MAPT | P10636 | 5/20 | 0.83 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.83 |
| ▸ | PDE5A | O76074 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | LATS1 | O95835 | 1/20 | 0.61 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201579 | 0.86 | ABCG2 (0.85) | ABCG2MAPTABCB1SMN1; SMN2PDE5A | |
| SCHEMBL8093527 | 0.86 | ABCG2 (0.82) | ABCG2MAPTPDE5AMEN1KMT2A | |
| SCHEMBL8094111 | 0.85 | MAPT (0.67) | ABCG2MAPTABCB1SMN1; SMN2PDE5A | |
| SCHEMBL13945465 | 0.83 | MEN1 (0.82) | ABCG2MAPTABCB1SMN1; SMN2PDE5A | |
| SCHEMBL28092379 | 0.82 | MAPT (0.69) | ABCG2MAPTABCB1SMN1; SMN2PDE5A | |
| SCHEMBL4867505 | 0.82 | ABCG2 (1.00) | ABCG2MAPTPDE5AMEN1KMT2A | |
| SCHEMBL5531993 | 0.82 | ABCG2 (0.89) | ABCG2MAPTABCB1SMN1; SMN2PDE5A | |
| SCHEMBL16404316 | 0.81 | ABCG2 (0.74) | ABCG2MAPTABCB1SMN1; SMN2PDE5A | |
| SCHEMBL1064901 | 0.80 | TGFBR1 (0.82) | ABCG2MAPTABCB1SMN1; SMN2PDE5A | |
| SCHEMBL16404340 | 0.79 | ABCG2 (0.72) | ABCG2MAPTABCB1SMN1; SMN2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000085-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES USEFUL AS MODULATORS OF GATED ION CHANNELS | PAINCEPTOR PHARMA CORPORATION (CA) | 2008-12-31 | — | — | WO | disclosed |