Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136241 | 0.88 | TOP2A (0.47) | TOP2ATOP2BNOTUMCYP11B2 | |
| SCHEMBL10817331 | 0.88 | TOP2A (0.47) | TOP2ATOP2BPIM1GSK3AGSK3B | |
| SCHEMBL4305779 | 0.85 | TOP2A (0.42) | TOP2ATOP2BGSK3BALDH1A1KDM4E | |
| SCHEMBL7121568 | 0.83 | TOP2A (0.41) | TOP2ATOP2BPIM1GSK3AGSK3B | |
| SCHEMBL4300362 | 0.83 | TOP2A (0.39) | TOP2ATOP2BCYP11B2 | |
| SCHEMBL3129267 | 0.83 | TOP2A (0.39) | TOP2ATOP2B | |
| SCHEMBL23037281 | 0.82 | TOP2A (0.47) | TOP2ATOP2BALDH1A1KDM4E | |
| SCHEMBL9428229 | 0.82 | TOP2A (0.40) | TOP2ATOP2BGSK3BALDH1A1KDM4E | |
| SCHEMBL11004379 | 0.81 | KDM4E (0.44) | TOP2ATOP2BPIM1GSK3AGSK3B | |
| SCHEMBL27741279 | 0.80 | TOP2A (0.37) | TOP2ATOP2BGSK3BNOTUMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6018054-A | INTERMEDIATE COMPOUNDS FOR PREPARING NOVEL QUINOLONE AND NAPHTHYRIDONE DERIVATIVES WHICH ARE SUBSTITUTED IN THE 7-POSITION BY A PARTIALLY HYDROGENATED ISOINDOLINYL RING, USE AS ANTIBACTERIAL AGENTS AND AS FEED ADDITIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| US-5739339-A | BACTERICIDES, ANTIPROTOZOA AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-04-14 | — | — | US | disclosed |
| US-5556979-A | ANIMAL FEEDS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-09-17 | — | — | US | disclosed |
| EP-0588166-B1 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1996-06-05 | — | — | EP | disclosed |
| CN-1087634-A | 7-Isoindolinyl-quinolone derivatives and 7-isoindolinyl-naphthyridone derivatives | BAYER AG (DE) | 1994-06-08 | — | — | CN | disclosed |
| EP-0588166-A2 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-03-23 | — | — | EP | disclosed |
| US-5182401-A | Bactericide intermediate | BAYER AKTIENGESELLSCHAFT (DE) | 1993-01-26 | — | — | US | disclosed |
| US-4945160-A | Preparation of certain 7-substituted quinolones | WARNER-LAMBERT COMPANY (US) | 1990-07-31 | — | — | US | disclosed |