Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4305779 | 0.86 | TOP2A (0.42) | TOP2ATOP2B | |
| SCHEMBL4300362 | 0.84 | TOP2A (0.39) | TOP2ATOP2B | |
| SCHEMBL9428229 | 0.83 | TOP2A (0.40) | TOP2ATOP2B | |
| SCHEMBL8096676 | 0.83 | TOP2A (0.47) | TOP2ATOP2B | |
| SCHEMBL3136241 | 0.80 | TOP2A (0.47) | TOP2ATOP2B | |
| SCHEMBL9262116 | 0.80 | TOP2A (0.39) | TOP2ATOP2B | |
| SCHEMBL10817331 | 0.77 | TOP2A (0.47) | TOP2ATOP2B | |
| SCHEMBL7121568 | 0.73 | TOP2A (0.41) | TOP2ATOP2B | |
| SCHEMBL3808229 | 0.73 | TOP2A (0.32) | TOP2ATOP2B | |
| Fluoride SCHEMBL7804252 | 0.73 | TOP2A (0.56) | TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056633-A2 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-20 | — | — | WO | disclosed |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | NQO2, QRFPR, NQO1 | TOP2A 389/4885TOP2B 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.