Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10530946 | 0.79 | LMNA (0.49) | LMNAGAABCAT1ALDH1A1POLB | |
| SCHEMBL489291 | 0.79 | LMNA (0.49) | LMNAGAABCAT1ALDH1A1POLB | |
| SCHEMBL29816630 | 0.79 | LMNA (0.49) | LMNAGAABCAT1ALDH1A1KMT2A | |
| SCHEMBL7534421 | 0.74 | GAA (0.44) | LMNAGAABCAT1ALDH1A1KDM4E | |
| SCHEMBL7534420 | 0.74 | GAA (0.44) | LMNAGAABCAT1ALDH1A1KDM4E | |
| SCHEMBL4972178 | 0.74 | LMNA (0.70) | LMNAGAABCAT1ALDH1A1KDM4E | |
| SCHEMBL4110091 | 0.74 | LMNA (0.70) | LMNAGAABCAT1ALDH1A1KDM4E | |
| SCHEMBL6229583 | 0.73 | LMNA (0.54) | LMNAGAABCAT1ALDH1A1POLB | |
| SCHEMBL6229585 | 0.73 | LMNA (0.54) | LMNAGAABCAT1ALDH1A1POLB | |
| SCHEMBL7262048 | 0.73 | GAA (0.67) | LMNAGAABCAT1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008153857-A1 | DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008133896-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-11-06 | — | — | WO | disclosed |