Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 7/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.36 |
| ▸ | RET | P07949 | 4/20 | 0.36 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.36 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083835 | 0.92 | MTOR (0.39) | MTORKDRFGFR1EGFRPIK3CD | |
| SCHEMBL8096057 | 0.92 | MTOR (0.43) | MTORPIK3CDPIK3CAATR | |
| SCHEMBL8097088 | 0.86 | TSHR (0.47) | PIK3CDPIK3CAAURKBMAPK1 | |
| SCHEMBL8097556 | 0.86 | PIK3CA (0.42) | MTORPIK3CDPIK3CAATR | |
| SCHEMBL8097252 | 0.84 | CA12 (0.43) | MTORPIK3CDPIK3CAEPHX2ATR | |
| SCHEMBL8098293 | 0.84 | PIK3CA (0.42) | MTORPIK3CDPIK3CAATR | |
| SCHEMBL8103635 | 0.83 | ATR (0.39) | MTORPIK3CDPIK3CAATR | |
| SCHEMBL8089909 | 0.83 | MTOR (0.45) | MTORPIK3CDPIK3CADYRK1A | |
| SCHEMBL8091635 | 0.83 | ATR (0.47) | MTORKDRFGFR1PIK3CDPIK3CA | |
| SCHEMBL8098306 | 0.82 | CA12 (0.42) | MTORKDRPIK3CDPIK3CAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |