Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104382 | 0.92 | MTNR1A (0.58) | MTNR1AMTNR1BHPGDKDM1ATAAR1 | |
| SCHEMBL8104774 | 0.92 | CNR2 (0.48) | MTNR1AMTNR1B | |
| SCHEMBL8104776 | 0.92 | CNR2 (0.48) | MTNR1AMTNR1B | |
| SCHEMBL8097843 | 0.92 | CNR2 (0.48) | MTNR1AMTNR1B | |
| SCHEMBL8097840 | 0.92 | CNR2 (0.48) | MTNR1AMTNR1B | |
| SCHEMBL8098442 | 0.91 | MTNR1A (0.60) | MTNR1AMTNR1BHPGDTAAR1 | |
| SCHEMBL8098444 | 0.91 | MTNR1A (0.60) | MTNR1AMTNR1BHPGDTAAR1 | |
| SCHEMBL8096171 | 0.91 | MTNR1A (0.55) | MTNR1AMTNR1BHPGDKDM1ATAAR1 | |
| SCHEMBL8096172 | 0.91 | MTNR1A (0.55) | MTNR1AMTNR1BHPGDKDM1ATAAR1 | |
| SCHEMBL8104747 | 0.90 | MTNR1A (0.59) | MTNR1AMTNR1BHPGDTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |