Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085124 | 0.88 | NAMPT (0.35) | MAPK1PIK3CDCA12CA1CA2 | |
| SCHEMBL8085149 | 0.88 | PIK3CA (0.39) | MAPK1PIK3CDRAB9APIK3CAKDR | |
| SCHEMBL8093434 | 0.86 | PIK3CD (0.35) | MAPK1PIK3CDPOLBRAB9APIK3CA | |
| SCHEMBL8097960 | 0.86 | KDM4E (0.38) | PIK3CDPOLBRAB9APIK3CAKDR | |
| SCHEMBL8098658 | 0.85 | MAPT (0.37) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8098657 | 0.85 | MAPT (0.37) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8091977 | 0.85 | PIK3CD (0.35) | PIK3CDPOLBRAB9APIK3CA | |
| SCHEMBL8090804 | 0.84 | MTOR (0.37) | PIK3CDPOLBRAB9APIK3CAKDR | |
| SCHEMBL8091937 | 0.84 | CA12 (0.39) | MAPK1PIK3CDCA12CA1CA2 | |
| SCHEMBL8089088 | 0.84 | PIK3CA (0.40) | MAPK1PIK3CDRAB9APIK3CAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |