Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.35 |
| ▸ | F7 | P08709 | 7/20 | 0.31 |
| ▸ | F2 | P00734 | 3/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085149 | 0.89 | PIK3CA (0.39) | PIK3CDPIK3CAALDH1A1GAARAB9A | |
| SCHEMBL8097960 | 0.88 | KDM4E (0.38) | PIK3CDPIK3CAALDH1A1GAAPOLB | |
| SCHEMBL8098772 | 0.86 | PIK3CD (0.39) | PIK3CDPIK3CARAB9A | |
| SCHEMBL8089088 | 0.86 | PIK3CA (0.40) | PIK3CDPIK3CAALDH1A1GAARAB9A | |
| SCHEMBL8093434 | 0.85 | PIK3CD (0.35) | PIK3CDPIK3CAPOLBRAB9A | |
| SCHEMBL8097954 | 0.85 | MAPK1 (0.33) | PIK3CDPIK3CAPOLBRAB9A | |
| SCHEMBL8090804 | 0.84 | MTOR (0.37) | PIK3CDPIK3CAPOLBRAB9A | |
| SCHEMBL8096194 | 0.84 | KDM4E (0.39) | PIK3CDPIK3CAALDH1A1GAAPOLB | |
| SCHEMBL8100085 | 0.84 | NAMPT (0.38) | PIK3CDPIK3CAF7F2 | |
| SCHEMBL8089527 | 0.84 | PIK3CD (0.41) | PIK3CDPIK3CAF7F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |