Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089088 | 0.89 | PIK3CA (0.40) | MTORPIK3CAPIK3CGPIK3CDRAB9A | |
| SCHEMBL8098772 | 0.89 | PIK3CD (0.39) | MTORPIK3CAPIK3CGPIK3CDRAB9A | |
| SCHEMBL8089090 | 0.88 | KDR (0.39) | MTORPIK3CAPOLBRAB9AKMT2A | |
| SCHEMBL8096194 | 0.88 | KDM4E (0.39) | MTORPIK3CAPIK3CGPIK3CDPOLB | |
| SCHEMBL8096192 | 0.88 | PIK3CD (0.36) | MTORPIK3CAPIK3CGPIK3CDPOLB | |
| SCHEMBL8084738 | 0.87 | PIK3CA (0.40) | MTORPIK3CARAB9AKMT2AKDR | |
| SCHEMBL8082082 | 0.87 | PIK3CA (0.38) | MTORPIK3CARAB9AKMT2AKDR | |
| SCHEMBL8085149 | 0.86 | PIK3CA (0.39) | MTORPIK3CAPIK3CGPIK3CDRAB9A | |
| SCHEMBL8095459 | 0.86 | MTOR (0.37) | MTORPIK3CAPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL8091977 | 0.84 | PIK3CD (0.35) | PIK3CAPIK3CDPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |