Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084988 | 0.85 | RAB9A (0.41) | RAB9ANPC1POLBMTORKMT2A | |
| SCHEMBL8100159 | 0.85 | PIK3CA (0.36) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL8106629 | 0.83 | PIK3CD (0.34) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL8106631 | 0.83 | CYP1A2 (0.35) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL8091770 | 0.81 | MTOR (0.37) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL4207101 | 0.81 | PIK3CA (0.54) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL8098837 | 0.80 | PIK3CA (0.40) | MTORKMT2AMEN1PIK3CDPIK3CA | |
| SCHEMBL11925854 | 0.77 | RAB9A (0.48) | RAB9ANPC1POLBMTORKMT2A | |
| SCHEMBL4011751 | 0.77 | PIK3CA (0.57) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL8091352 | 0.76 | PIK3CA (0.41) | RAB9ANPC1MTORPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |